interactions of St John's Wort
Last reviewed 01/2018
The CSM has advised that St John's Wort should not be used with:
- indinavir
- warfarin
- cyclosporin
- oral contraceptives
- theophylline
- digoxin
Although there is no direct evidence, it is likely that clinically important interactions may occur with:
- other HIV protease inhibitors (saquinavir, nelfinavir ritonavir)
- HIV non-nucleoside reverse transcriptase inhibitors (nevirapine, efavirnez)
- anticonvulsants (phenobarbitone, phenytoin, carbamazepine)
Additionally St John's Wort:
- may interact with selective serotonin reuptake inhibitors
- may have pharmacodynamic interactions with the triptans used to treat migraine
Reference:
- CEM/CMO/2000/4
cyclosporin and St John's wort
oral contraceptives and St John's wort
anticonvulsants and St John's wort