verapamil and hyperprolactinaemia
Last reviewed 01/2018
- verapamil has a significant prolactin releasing effect - a study revealed
that 8.5% of male patients treated with verapamil had increased prolactin
levels with a concomitant reduction in testosterone levels (1) - this prolactin
releasing effect is not significant with other calcium antagonists
- verapamil may lead to hyperprolactinaemia via antagonism of N-type calcium channels and consequent decrease in central dopamine production
Reference:
- 1) Romeo JH et al. Hyperprolactinaemia and verapamil: prevalence and potential association with hypogonadism in men. Clin Endocrinol (Oxf) 1996;45:571-5.