unconjugated hyperbilirubinaemia
Last reviewed 01/2018
Causes include:
- increased bilirubin formation:
- haemolysis
- ineffective erythropoiesis:
- megaloblastic anaemia
- iron deficiency
- haemoglobinopathies
- failure of bilirubin uptake:
- Gilbert's disease
- failure of bilirubin conjugation:
- neonatal jaundice
- Crigler Najjar syndrome
- drug inhibition e.g. chloramphenicol
- extensive hepatocellular disease e.g. hepatitis, cirrhosis