subacute cutaneous lupus erythematosus
Last reviewed 01/2018
This form of LE comprises up to 10% of SLE cases and is characterised by the presence of persistent macular or slightly raised erythematous lesions on the upper trunk and arms. Females are affected more than males.
Serology:
- circulating anti-Ro, anti-La antibodies and rheumatoid factor may be found.
- mild hypocomplimentaemia.
Features:
- tends to be benign - life-threatening systemic involvement tends to be uncommon.
Treatment:
- topical steroids and intralesional steroids.
- if topical therapy is not sufficient then alternatives include:
- prednisolone and cytotoxic drugs
- other antimalarial drugs eg mepacrine. Mepacrine may be used in combination with hydroxychloroquine